戴建业教授一直致力于发展适应中药特点的药效靶标鉴定及分子机制研究方法。经过10余年的探索，戴建业教授以中药黄芩为例，逐步形成了覆盖中药药理学不同层次研究的“四横四纵”（四横：中药复方-单味药-有效部位-活性单体四种对象逐层递进，四纵：整体-细胞-蛋白-位点四个层面步步深化）的技术体系。该技术体系打通了中药现代适应症确证、药效机制发现、创新药物研发的关键环节，实现了多点突破。同时，针对中药药效机制深度研究及新药研发过程中存在的问题，戴建业教授采取了多学科交叉的策略，攻克了精准靶标垂钓-定量活性检测-精细机制研究等技术难题，助力中药原始创新研究。上述研究得到了科技部重点研发计划子课题（2018YFC1706305，主持）、国家自然科学基金青年项目（82104527，主持）、甘肃省自然科学基金重点项目（20JR10RA586，主持）、西藏自治区科技计划项目重大科研专项（XZ202101ZD 0022G，主持）等项目支持。
1.He Rupu, Ma Ruyun, Jin Zheng, Zhu Yanning, Yang Fude, Hu Fangdi, Dai Jianye#(通讯作者). Proteomics and Metabolomics Unveil Codonopsis pilosula (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions via Regulating Energy Metabolism. Frontiers in Pharmacology. 2022, 13:933096. doi: 10.3389/fphar.2022.933096.
2.Cao Huijuan*, Zhou Wei*, Xian Xiaole*, Sun Shujun, Ding Peijie, Tian Chunyu, Tian Fuling, Jiang Chunhua, Fu Tingting, Zhao Shu, Dai Jianye#(通讯作者), A Mixture of Baicalein, Wogonin, and Oroxylin-A Inhibits EMT in the A549 Cell Line via the PI3K/AKT-TWIST1-Glycolysis Pathway, Frontiers in Pharmacology, 2022, 12: 0-821485
3.Wei Xu*, Qi Baoyu*, Ma Ruyun*, Zhang Yili, Liu Ning, Fang Shengjie, Zhu Yanning, Xie Yanming#, Dai Jianye#(共同通讯作者), Zhu Liguo#, Quantitative Proteomics Revealed the Pharmacodynamic Network of Bugu Shengsui Decoction Promoting Osteoblast Proliferation, Front Endocrinol (Lausanne), 2022,12: 0-833474
4.魏君楠, 戴建业, 中草药活性成分直接作用靶点鉴定研究方法及应用, 中草药, 2021,52(17), 1-113.
5.Zhou Wei*, Dong Min*, Wu Hao*, Li Huilin, Xie Jiale, Ma Ruyun, Su Weiwei#, Dai Jianyei#(共同通讯作者), Common mechanism of Citrus Grandis Exocarpium in treatment of chronic obstructive pulmonary disease and lung cancer, Chinese Herbal Medicines, 2021(13) 525–533
6.He Rupu, Jin Zheng, Ma Ruyun, Hu Fangdi#, Dai Jianye#(共同通讯作者), Network pharmacology unveils spleen-fortifying effect of Codonopsis Radix on different gastric diseases based on theory of “same treatment for different diseases” in traditional Chinese medicine, Chinese Herbal Medicines,2021(2),189-2012.
7.Ma Yanrong, Xin Mingyan, Wen Yuanjie, Wang Huan, Zhang Guoqiang, Dai Jianye#(共同通讯作者), Wu Xin-An#, The utility of endogenous glycochenodeoxycholate-3-sulfate and 4β-hydroxycholesterol to evaluate the hepatic disposition of atorvastatin in rats, Asian Journal of Pharmaceutical Sciences, 2021, https://doi.org/10.1016/j.ajps.2021.03.002 (期刊论文)
8.Dang Zefang* ; Li Qianhua* ; Sun Shujun* ; Wang Yang* ; Lin Rui; Zhang Yongyu# ; Dai Jianye#(共同通讯作者); Zheng Ningning#, The Medicinal Plant Pair Bupleurum chinense -Scutellaria baicalensis-Metabolomics and Metallomics Analysis in a Model for Alcoholic Liver Injury, Frontiers in Pharmacology, 2019, 10:254, 10.3389/fphar.2019.00254 (期刊论文)
9.Dai Jianye* ; Liang Kai; Zhao Shan; Jia Wentong; Liu Yuan; Wu Hongkun; Lv Jia; Cao Chen; Chen Tao; Zhuang Shentian; Hou Xiaomeng; Zhou Shijie; Zhang Xiannian; Chen Xiao Wei; Huang Yanyi; Xiao Rui Ping; Wang Yan Ling; LuoTuoping; Xiao Junyu; Wang Chu# ,Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis , Proceedings of the National Academy of Sciences of the United States of America, 2018.06.26, 115(26): E5896-E5905 (期刊论文)
