【基本情况】
        博士/博士后，教授/博导，甘肃省飞天学者，甘肃省陇原青年创新创业团队负责人，甘肃省中藏药功效物质开发与利用行业技术中心负责人，天然药物化学生物学研究所所长。曾任3777金沙娱场城院长，甘肃省药学会副理事长。现兼任中国民族医药协会民族医药教育专业委员会副会长，世界中联中医与农业产业分会第一届专家委员会委员，中国生物医药整合联盟理事，中国民族医药协会芳香医药分会副主任委员，甘肃省院内制剂产业技术创新战略联盟副理事长，甘肃省化学会理事、甘肃省化学会药物化学主任委员和甘肃省药学会天然药物与医药产业经济主任委员等职务。近年来，课题组以“天然药物化学生物学”为主要研究方向，系统开展了基于中药与天然源生物活性功能分子的先导发现、多样性导向合成、药效评价及其应用开发研究，其成果先后在Med. Res. Rev.、J. Med. Chem、Europ. J. Med. Chem等高水平SCI论文发表80余篇，受邀以“西部及一带一路中药及药用植物资源“为主题在药物化学Top杂志Med. Res. Rev.撰写了专题性系列综述，作为副主编参编论著3部。申请国家发明专利百余件，PCT专利1件，成果转化5项。承担国家重点研发计划、国家自然科学基金、甘肃省重点研发计划、甘肃省科技创新专项等科技项目30余项，服务企业合作横向项目以及与企业联合的产学研课题50余项。

【研究方向】

    课题组主要研究方向：天然药物化学生物学，其主要聚焦：[1] 抗肿瘤药物的先导发现、设计合成及其应用开发；[2] 抗菌药物的先导发现、设计合成及其应用开发。

【主讲课程】
        主讲药学专业本科生课程：《有机化学》课程的教学工作。承担研究生《有机合成导论》课程和药物化学以及天然药物化学生物学专业研究生的培养工作。

【获奖情况】

   先后荣获西部药学之星、甘肃药学会药学发展一、二等奖、中华中医药学会科学技术奖、南京市科技进步三等奖等奖励。

[1] Mei-Juan Wang, Ying-Qian Liu,* Ling-Chu Chang, Chih-Ya Wang, Yong-Long Zhao, Xiao-Bo Zhao, Keduo Qian, Xiang Nan, Liu Yang, Xiao-Ming Yang, Hsin-Yi Hung, Jai-Sing Yang, Daih-Huang Kuo, Masuo Goto, Susan L. Morris-Natschke, Shiow-Lin Pan, Che-Ming Teng, Sheng-Chu Kuo, Tian-Shung Wu, Yang-Chang Wu, Kuo-Hsiung Lee*. Design, Synthesis, Mechanisms of Action, and Toxicity of Novel 20(S)-Sulfonylamidine Derivatives of Camptothecin as Potent Antitumor Agents. J. Med. Chem. 2014, 57, 6008～6018.

[2] Liang Kou, Mei-Juan Wang, Li-Ting Wang, Xiao-Bo Zhao, Xiang Nan, Liu Yang, Ying-Qian Liu*, Susan L. Morris-Natschke, Kuo-Hsiung Lee*. Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions. Europ. J. Med. Chem. 2014, 75, 282～288.

[3] Xiao-Bo Zhao, Masuo Goto, Zi-Long Song, Susan L. Morris-Natschke, Yu Zhao, Dan Wu, Liu Yang, Shu-Gang Li, Ying-Qian Liu*, Gao-Xiang Zhu, Xiao-Bing Wu, Kuo-Hsiung Lee*. Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents. Bioorg. Med. Chem. Lett. 2014, 24, 3850～3853.

[4] Xiao-Bo Zhao, Dan Wu, Mei-Juan Wang, Masuo Goto, Susan L. Morris-Natschke, Ying-Qian Liu*, Xiao-Bing Wu, Zi-Long Song, Gao-Xiang Zhu, Kuo-Hsiung Lee*. Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents. Bioorg. Med. Chem. Lett. 2014, 22, 6453～6458.

[5] Ying-Qian Liu, Wen-Qun Li, Susan L. Morris-Natschke, Keduo Qian, Liu Yang, Gao-Xiang Zhu, Xiao-Bing Wu, An-Liang Chen, Shao-Yong Zhang, Xiang Nan, Kuo-Hsiung Lee*. Perspectives on Biologically Active Camptothecin Derivatives. Med. Res. Rev. 2015, 35, 753-789.

[6] Zi-Long Song, Hai-Le Chen, Yu-Han Wang, Masuo Goto, Wen-Jing Gao, Pi-Le Cheng, Susan L. Morris-Natschke, Ying-Qian Liu*, Gao-Xiang Zhu, Mei-Juan Wang, Kuo-Hsiung Lee*. Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction. Bioorg. Med. Chem. Lett. 2015, 25, 2690～2693.

[7] Ying-Qian Liu, Jing Tian, Keduo Qian, Xiao-Bo Zhao, Susan L. Morris-Natschke, Liu Yang, Xiang Nan, Xuan Tian,  Kuo-Hsiung Lee*. Recent Progress on C-4-Modified Podophyllotoxin Analogs as Potent Antitumor Agents. Med. Res. Rev. 2015, 35, 1～62.

[8] Zi-Long Song, Mei-Juan Wang, Lanlan Li, Dan Wu, Yu-Han Wang, Li-Ting Yan, Susan L. Morris-Natschke, Ying-Qian Liu*, Yong-Long Zhao, Chih-Ya Wang, Huan-xiang Liu*, Masuo Goto, Heng Liu, Gao-Xiang Zhu, Kuo-Hsiung Lee*. Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives. Europ. J. Med. Chem. 2016, 115, 109～120.

[9] Cheng-Jie Yang, Zi-Long Song, Masuo Goto, Pei-Ling Hsu, Xiao-Shuai Zhang, Qian-Ru Yang, Ying-Qian Liu*, Mei-Juan Wang, Susan L. Morris-Natschke, Xiao-Fei Shang, Kuo-Hsiung Lee*. Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives. Bioorg. Med. Chem. Lett. 2017, 27, 4694～4697.

[10] Cheng-Jie Yang, Zi-Long Song, Masuo Goto, Ying-Qian Liu*, Kan-Yen Hsieh, Susan L. Morris-Natschke, Yong-Long Zhao, Jun-Xiang Zhang, Kuo-Hsiung Lee*. Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties. Bioorg. Med. Chem. Lett. 2017, 27, 3959～3962.

[11] Gao-Xiang Zhu, Pi-Le Cheng, Masuo Goto, Na Zhang, Susan L. Morris-Natschke, Kan-Yen Hsieh,Guan-Zhou Yang, Qian-Ru Yang, Ying-Qian Liu*, Hai-Le Chen, Xiao-Shuai Zhang, Kuo-Hsiung Lee*. Design, synthesis and potent cytotoxic activity of novel 7-( N -[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives. Bioorg. Med. Chem. Lett. 2017, 27, 1750～1753.

[12] Xiao-Fei Shang, Susan L. Morris-Natschke, Guan-Zhou Yang, Ying-Qian Liu*, Xiao Guo, Xiao-Shan Xu, Masuo Goto, Jun-Cai Li, Ji-Yu Zhang, Kuo-Hsiung Lee*. Biologically active quinoline and quinazoline alkaloids part II. Med. Res. Rev. 2018, 38, 1614～1660.

[13] Xiao-Fei Shang, Susan L., Morris-Natschke, Ying-Qian Liu*, Xiao Guo, Xiao-Shan Xu, Masuo Goto, Jun-Cai Li, Guan-Zhou Yang, Kuo-Hsiung Lee*. Biologically active quinoline and quinazoline alkaloids part I. Med. Res.Rev. 2018, 38, 775～828.

[14] Jun-cai Li, Ren-xuan Wang, Yu Sun, Jia-kai Zhu, Guan-fang Hu, Yu-ling Wang, Rui Zhou, Zhong-min Zhao, Ying-qian Liua*, Jing-wen Peng, Yin-fang Yan, Xiao-fei Shang. Design, synthesis and antifungal activity evaluation of isocryptolepine derivatives. Bioorg. Chem. 2019, 92, 103266.

[15] Xiao-Fei Shang, Li-Xia Dai, Ying-Qian Liu*, Zhong-Min Zhao, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Acaricidal activity and enzyme inhibitory activity of active compounds of essential oils against Psoroptes cuniculi. Vet. Parasitol. 2019, 267, 54～59.

[16] Guan-Zhou Yang, Jia-Kai Zhu, Xiao-Dan Yin, Yin-Fang Yan, Yu-Ling Wang, Xiao-Fei Shang, Ying-Qian Liu*, Zhong-Min Zhao, Jing-Wen Peng, Hua Liu. Design, synthesis, and antifungal evaluation of novel quinoline derivatives inspired from natural quinine alkaloids. J. Agric. Food Chem. 2019, 67, 11340～11353.

[17] Xiao-Fei Shang, Cheng-Jie Yang, Susan L. Morris-Natschke, Jun-Cai Li, Xiao-Dan Yin, Ying-Qian Liu*, Xiao Guo, Jing-Wen Peng, Masuo Goto, Ji-Yu Zhang, Ku-Hsiung Lee*. Biologically active isoquinoline alkaloids covering 2014–2018. Medicinal Research Reviews, 2020, 40, 1～78.

[18] Cheng-Jie Yang, Bin Li, Zhi-Jun Zhang, Jian-Mei Gao, Mei-Juan Wang, Xiao-Bo Zhao, Zi-Long Song, Ying-Qian Liu*, Hu Li, Yu-yuan Chen, Kuo-Hsiung Lee, Susan L. Morris-Natschke, Chuan-rui Xu. Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin. Europ. J. Med. Chem. 2020, 187, 111971.

[19] Yu-YuanChen,Yin-Peng Bai, Bin Li, Xiao-BoZhao, Cheng-JieYang, Ying-Qian Liu*, Jian-MeiGao, JunGuo, Chun Li, Jing-WenPeng, Zhong-MinZhao, Zhi-JunZhang, Chuan-RuiXu*. Design and synthesis of novel 20(S)-α-aminophosphonate derivatives of camptothecin as potent antitumor agents. Bioorg. Chem. 2021,114, 105065.

[20] Junmin Zhang, Susan L. Morris-Natschke, Di Ma, Xiao-Fei Shang,  Chen-Jie Yang, Ying-Qian Liu*, Kuo-Hsiung Lee*. Biologically active indolizidine alkaloids. Med Res Rev. 2021, 41, 928～960.

1.主持国家自然科学基金面上项目（22177043):  融合多层次化学结构特征进行天然源白叶藤碱类生物碱全新杀菌化学实体的设计合成与结构优化研究，2022-01至2025-12。

2.主持国家自然科学基金面上项目(21877056): 源于天然源奎宁类生物碱的全新杀菌化学实体的设计合成与结构优化研究，2019-01至2022-12。

3.主持甘肃省重点研发计划国际科技合作专项(18YF1WA115): 巴基斯坦四种特色药用植物生物碱类活性成分的合作研究， 2018-01至2020-12。

4.承担科技部国家重点研发计划(2017YFD0201400):天然绿色生物农药的合成生物学与组合合成技术，2017-01至2020-12， 承担该项目的子课题4的“活性代谢物结构修饰和多样性衍生优化”任务。

5.主持国家自然科学基金面上项目(21672092): 新型自旋标记喹啉类拓扑异构酶抑制剂的设计合成及其生物活性研究，2017-01至2020-12。

6.主持国家自然科学基金面上项目(31371975):基于结构多样性策略进行喜树碱类生物碱的结构优化及其杀虫活性研究，2014-01至2017-12。

7.主持横向项目:《甘肃省中药炮制规范》（2009 年版）中药典品种特殊炮制规格标准制修订，2019-06至2020-01。

8.主持横向项目:新型生物活性先导结构的发现与活性评价研究（I、II），2017-04至2023-04。

9.主持横向项目: 新型兽用抑菌活性先导发现, 2020-09至2026-09。

10.主持横向项目: 多肽抗菌药物筛选，2019-06至2020-12。