【基本情况】 

 2000年毕业于四川大学并获理学学士学位，师从王子淑教授，2007年毕业于中国科学院生物物理研究所并获理学博士学位，师从郭爱克院士。后在新加坡国立大学，北京大学，伊利诺伊大学芝加哥分校，普渡大学，圣母大学作科学研究。在科学研究方面主要从事衰老，神经退行性疾病，微生物感染，心脑血管疾病，寄生虫，寄生虫/病毒载体等领域的研究。

 实验室目前专注于衰老及相关疾病研究，以细菌，酵母，果蝇，细胞，小鼠为模型，致力于开发抗糖尿病新药、抗心脑血管疾病新药、抗神经退行性疾病新药、抗肠胃溃疡新药等方向。现已发现新型药物先导化合物40余种、生物制剂8种、新靶标20余个。 

实验室已经申请专利31项，获批7项。转化成果5项，目前正在落地以下项目：高效无毒解酒食品、缓解痛风食品、缓解并防止胃溃疡复发食品、减肥新药、脑卒中新药、糖尿病新药、溃疡性结肠炎胃溃疡新药，欢迎投资者洽谈。新药类型包括小分子、AAV病毒、工程化益生菌。也欢迎有志于创业、学术研究的同学们参与项目训练。

 实验室以培养有创造性和前瞻性的一流科学家为主要目标，鼓励创新，鼓励合作，气氛融洽。本实验室常年招收各类研究人员。如对我们的研究方向感兴趣，请联系我们。  

【研究方向】

 开发可治愈糖尿病、心脑血管疾病、神经退行性疾病和胃肠溃疡新药。

1.Xiangxiang Li, Jing Zhou, Zhuozhou Hu, Liang Han, Wenyang Zhao, Tongyu Wu, Chun Li, Jingjing Liu, Jia Kang, Xinping Chen. Quinacrine attenuates diet-induced obesity by inhibiting adipogenesis via activation of AMPK signaling. Eur J Pharmacol. 2023, 938:175432.

2.Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. Alfuzosin ameliorates diabetes by boosting PGK1 activity in diabetic mice. Life Sci. 2023, 317:121491.

3.Zhuozhou Hu, Chun Li, Tongyu Wu, Jing Zhou, Liang Han, Jingjing Liu, Shaojia Qiang, Wenyang Zhao, Xiangxiang Li, Xiaohua Liu, Jiazhong Li, Xinping Chen. Sulfathiazole treats type 2 diabetes by restoring metabolism through activating CYP19A1. BBA - General Subjects. 2023, 1867:130303.

4.Tongyu Wu, Chun Li, Jing Zhou, Liang Han, Shaojia Qiang, Zhuozhou Hu, Jingjing Liu, Xiangxiang Li, Wenyang Zhao, Xinping Chen. Primaquine activates Keratin 7 to treat diabetes and its complications. J Diabetes Metab Disord. 2022, 21(2):1731-1741.

5.Jingjing Liu, Wenyang Zhao, Chun Li, Tongyu Wu, Liang Han, Zhuozhou Hu, Xiangxiang Li, Jing Zhou, Xinping Chen. Terazosin Stimulates Pgk1 to Remedy Gastrointestinal Disorders. Int. J. Mol. Sci. 2022, 23:416.

6.Zhuozhou Hu, Jing Zhou, Liang Han, Xiangxiang Li, Chun Li, Tongyu Wu, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen. Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice. Life Sci. 2022, 304:120725.

7.Liang Han, Jing Zhou, Zhuozhou Hu, Chenggong Fu, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Tongyu Wu, Chun Li, Jia Kang, Jiazhong Li, Xinping Chen. Lamivudine remedies alcoholism by activating acetaldehyde dehydrogenase. Biochem Pharmacol. 2022, 203:115199.

8.Xinping Chen, Hana Hall, Jeffrey Simpson, Walter Leon-Salas, Donald Ready, Vikki Weake. Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration. npj Aging and Mechanisms of Disease. 2017, 3:18.

9.Xinping Chen, Walter D. Leon-Salas, Taylor Zigon, Donald F. Ready, Vikki M. Weake. A programmable optical stimulator for the Drosophila eye. HardwareX. 2017, 2:13-33.

10.Xinping Chen, Chunyue Zhao, Xiaolong Li, Tao Wang, Yizhou Li, Cheng Cao, Yuehe Ding, Mengqiu Dong, Lorenzo Finci, Jia-huai Wang, Xiaoyu Li, Lei Liu. Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nat. Chem. Biol. 2015, 11:19-25.

11.Xinping Chen, Yan Li, Junbo Huang, Dawei Cao, Guoying Yang, Weijie Liu, Huimin Lu, Aike Guo. Study of tauopathies by comparing Drosophila and human tau in Drosophila. Cell. Tissue. Res. 2007, 329:169-178.